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Cristiano Ronaldo is the undisputed star man in this Selecao side, having netted 81 goals in 150 internationals.
The Real Madrid star is expected to partner with Andre Silva in the attack line.
Fernandes has no new injuries problems in his team ahead of this clash.
Meanwhile, Fernando Hierro’s Spain head into this clash with his side holding the best defensive record during the World Cup qualifiers.
Hierro’s men won 2, drew 3 of their last 5 games against Russia, Germany, Argentina, Switzerland and Tunisia.
Spain’s fitness doubt ahead of their opening fixture is Dani Carvajal, who limped off in Real Madrid’s Champions League final victory against Liverpool and has only just returned to training.
Alvaro Odriozola would be the obvious replacement at right-back, while the rest of the back five, including the tournament’s best goalkeeper in David de Gea should remain unchanged.
Hierro has a decision to make in central midfield, where Andres Iniesta and Sergio Busquets are expected to be joined by one of Thiago Alcantara or Koke, while up top Diego Costa is favourite to get the nod